This course covers basics of genes, genomes, sequencing technologies, and use of bioinformatic databases. This first version has been designed specifically with the participants of the Helminth Bioinformatics Course Asia 2021 (Connecting Sciences Courses & Conferences) in mind; therefore, the contents focus on eukaryotic genomes and eukaryotic databases, with a couple of special mentions related to parasitic worms. The overall contents of this course are relevant to all who are interested in genomics, transcriptomics, next-generation sequencing, and bioinformatics. The course content assumes no prior information in any of these areas, but some background in college biology may be useful.